Optimization of preparation for cyanidenon-?-cyclodextrin inclusion compound by Box-Behnken design and response surface method / 中草药

ABSTRACT

Objective To optimize the formulation of cyanidenon-?-cyclodextrin inclusion compound.Methods Cyanidenon-?-cyclodextrin inclusion compound was prepared by saturated water solution method.The effects of influence factors,such as ingredient proportion,inclusion time,inclusion temperature on inclusion rate,obtaining rate,and overall desirability were investigated by using Box-Behnken design and response surface method.The data were imitated using multi-linear equation and second-order polynomial equation.Results The latter was prior to the former considering from multiple correlation coefficients.Under the optimal conditions,inclusion rate and yield were 75% and 66%,respectively.Conclusion The optimized preparation technique for cyanidenon-?-cyclodextrin inclusion compound is stable,feasible,and has high inclusion rate.It can be used for the production of cyanidenon-?-cyclodextrin inclusion compound.