Effects of angiotensin Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats / 重庆医科大学学报
Journal of Chongqing Medical University
; (12)2007.
Article
em Zh
| WPRIM
| ID: wpr-581230
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WPRO
ABSTRACT
Objective:To explore the effects of angiotens in Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats.Methods:38 SD male rats were divided into normal group,diabetic model group and angiotensin Ⅳ treatment group randomly.Streptozotocin-diabetic rat model was established and learning and memory behaviors were investigated using a spatial version of the Morris water maze test.The expression of Bcl-xl of all rats was examined with immunohistochemical method.Meanwhile,the hippocampal neuronal apoptosis were measured by TUNEL.Results:Learning and memory grade in the angiotensin Ⅳ treatment group were better than diabetic model group(P
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WPRIM
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Zh
Revista:
Journal of Chongqing Medical University
Ano de publicação:
2007
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Article