Effect of Blood Transfusion on Engraftment of Bone Marrow Cells in the Rat_s Exposed to the Lethal Dosage of Gamma-Irradiation / 中国输血杂志

ABSTRACT

The effect of blood transfusion on engraftment of bone marrow cells in the rats which are exposed to systemic irradiation by 10Gy of ?-ray of Co-60 was studied.All of the rats exposed to single irradiation did not show the recovery of white blood cell (WBC)counts and died after 4-8 days of irradiation.In the group with single bone marrow transplantation BMT),the incidence of WBC count recovery was 82%,which is consistent with the presence of the donor-type bone marrow cells.In both groups transfused with fresh whole blood and irradiated blood one day before BMT,the rate of bone marrow cell (BMC)engraftment was 100%,but the rate of BMC engraftment was only 30%,if the blood was transfused 5 days before BMT.In three groups transfused with stored blood,irradia- ted blood and fresh whole blood after BMT,the rates of BMC en- graftment were 100%,91% and 50% respectively.The results show that the effect of blood transfusion on BMC engraftment is associatad with the time of blood transfusion and the kind of transfused blood.