EFFECT OF C - PHYCOCYANIN ON GRANULOPOIESIS AND MONOCYTOPOIESIS IN MICE / 中国海洋药物

ABSTRACT

C - phycocyanin (C - PC) was isolated and purified from blue - green alga Spirulina platensis. By using the thechnique of culture of hemopoietic progenitor cell in vitro, we studied the effect of C -PC on granulopoiesis and monocytopoiesis in mice. The results indicate that C -PC can enhance the proliferation of CFU -GM, promote the granulopoiesis and monocytopoiesis in mice. The C -PC can markedly increase the colony stimulating activity of serum in normal mice. The prepared serum -free spleen cell conditioned media stimulated by C -PC in vivo and in vitro provided the only increase in CFU - GM colony formation. After in -vitro addition of C -PC in the presence of GM -CSF, there was a pronounced increase in the number of CFU -GM colonies.