Study on Type Ⅳ Collagenase and Type Ⅳ Collagen in Gastric Carcinoma of Nude Mice Transfered with TIMP-2 Gene / 中国肿瘤生物治疗杂志

ABSTRACT

The invasive model of gastric carcinoma in nude mice was constructed with gastric carcinoma cells SGC-7901 and SGC-7901-T2. The expression of type IVcollagenase (MT-MMP) and the changes of basement membrane (BM) in normal kidey tissue and malignant lesion of gastric were studied by immunohistochemical technique. The results showed that the positive rate of type IV collagenase(MT-MMP)was 36.6%in normal kidey tissue and 70% in malignant lesions (P