The changes of the blood sugar and the ?、? cells secretion function in a type 1 diabetic patient after pancreas-kidney joint-transplantation / 中国糖尿病杂志

ABSTRACT

Objective To evaluate the recovery of ? and ? cells secretion function and the effects on the blood sugar after the operation. By the comparison of the blood sugar,C peptide and the glucagon levels in the late type 1 diabetic patient with nephropathy before and after pancreas-kidney joint-transplantation. Methods Measuring and comparing the blood sugar,C peptide and glucagon, so as to assess the therapeutic effect of operations. Performing the insulin releasing test and glucose tolerance test on the 180th day after operation to acquaint the recovery of diabetes and the secretion function of ? cells. Results We found that before operation the patient's C peptide level was?obviously lower than normal,but the glucagon level was higher than normal. The blood sugar remained at higher level even then larger dose of insulin was applied. On the first day after operation, the C peptide secretion began to increase obviously and nearly exceeded normal level;the secretion of glucagon almost decreased to half of the preoperative level,but 30 days later,it decreased to normal; the blood sugar decreased to normal on the 7th day after operation. On the 20th day,the application of insulin were stopped, but within 240 days the blood sugar remained in normal range; 180 day after operation, the results of glucose tolerance tests and insulin releasing tests all remained normal. Conclusion The pancreas-kidney joint transplantation could improve the kidney function of the patient suffered from type 1 diabetic nephropathy,as well as treat diabetes by enhancing the secretion function of the pancreas ? cell. Pancreas-kidney joint-tranplantation is the best method to cure the nephropathy of late type 1 diabetes.