The effect of long term intelligence on NGF to the newborn rat with hypoxic-ischemic brain damage / 临床神经病学杂志

ABSTRACT

Objective To investigate the effect of long term intelligence on NGF to the newborn rats with hypoxic ischemic brain damage (HIBD).Methods The model of newborn rat hypoxic ischemic brain damage(HIBD) was set,0.01mg/10g dosage NGF and 0.03mg/10g dosage NGF were administered to the rat abdominal cavity respectively. With maze test, the change of learning memory abilities of long term in the rats were observed, the concentration of monoamine neurotransmitters in the brain tissue were determined by high performance liquid chromatography electrochemical detector.Results The function of learning and memory was better in NGF group(small, large amount group)than in the control group, the frequency was lower remarkably than the control group( P