Pathological study of Thrombolytic Compound on thrombolysis by internal carotid artery injection at superacute stage / 临床神经病学杂志

ABSTRACT

Objective To study the effect of Thrombolytic Compound (TC) injected into internal carotid at superacute stage.Methods 66 Wistar rats were divided into group A,B and C randomly. Focal cerebral ischemic model was established by improved microthromboembolus method. The rats were intubated conversely into internal carotid 3h after cerebral ischemia for treatment with normal saline (group A),Urokinase(group B) and TC(group C) respectively. The neural functions of these rats were evaluated at 2 h after cerebral ischemia,2.5 and 23.5h after treatment and pathological changes were observed under optic and electron microscopes 24 h following thrombolysis.Results There was no significant difference of neural function scores among the three groups before administration.The scores of group C were lower than those of group A after treatment ( P