The Dichotic Listening Research for Different Chinese Rhyming Words in Patients with Major Depressive Disorder by Focused Attention / 中国心理卫生杂志

ABSTRACT

Objective:To explore the brain function asymmetry characters of the patients with major depressive disorder (MDD).Methods:The study examined the ear advantage of 58 healthy subjects, 115 patients with MDD using two kinds of rhyming words by the method of focused attention. Results:1.In healthy group, no ear advantage was found in true words test, but appeared significant right ear (left-hemisphere) advantage in pseudo-words test. 2.In MDD group, there was also no ear advantage in true words test, but appeared enhanced right ear (left-hemisphere) advantage in pseudo-words test. There was a significant difference between the MDD and healthy subjects. Among patient group, 3. by true words test, no ear advantage was found in those with a comorbid anxiety disorder, but those without comorbid anxiety appeared right ear advantage. By pseudo-word test, both patients with or without comorbid anxiety appeared right ear (left-hemisphere) advantage, and those without had larger advantage. there was a significant difference between this two groups. 4.HAMD, HAMA and SCL-90 ratings had no relation to asymmetry scores of true words or that of pseudo-words.Conclusions:1. both healthy control and MDD patients have no ear advantage for process and cognition of true words in, but as for that of pseudo-words, both of them appear right ear (left-hemisphere) advantage, with the MDD patients have greater advantage. 2.The patients with or without a comorbid anxiety disorder were different in response, patients with comorbid anxiety appear more close to normal control. 4. Asymmetry scores don’t correlate significantly with the scores of HAMD, HAMA or SCL-90. 5.The pseudo-words is the better choice as stimuli for dichotic listening test.