Study on the relationship between expression of the intercellular adhesion molecule-1 and brain edema of hematoma peripheral zone after intracerebral hemorrhage in rats / 临床神经病学杂志

ABSTRACT

Objective In order to explore pathogenesis about inflammation injury of the hematoma peripheral zone after cerebral hemorrhage. Methods 48 adult male wistar rats are randomly divided into intracerebral hemorrhage (ICH) groupand control group. After 3 h, 24 h,72 h and 7 d of ICH, intercellular adhesion molecule-1 (ICAM-1)was detected by immunohistochemical SABC staining in rats brain slice. Positive cells expression of the ICAM-1 were measured by color image analysis system。Brain edema were assayed by dry-wet weight method. Results The expression of ICAM-1 increased at 3 h ( P 0.05) compared to contral group. Conclusions The overexpression of ICAM-1 may play important role in the perihematoma edema formation and ischemic injury.