Effects of ligustrazine on the endothelin-1-induced myocardial hypertrophy / 医学研究生学报

ABSTRACT

Objective: To investigate the action of tetramethylpyrazines on cardiac myocyte hypertrophy induced by endothelin-1(ET-1). Methods: The blockers of L-type calcium channel(Larcidipine),TMPP and TMPH were used to influence protein synthesis stimulated by chronic ET-1. Results:(ET-1) group's intracellular protein content in cardiac myocyte was(279?39)?g/ml(17% higher than the control group,P