Effect of Ginsenoside-Rg3 on proliferation activity of human keloid fibroblasts / 吉林大学学报(医学版)

ABSTRACT

Objective To study the direct inhibition of Ginsenoside-Rg3(GS-Rg3) on human keloid fibroblasts cultivated in vitro and its possible mechanism.Methods The effects of GS-Rg3 with different concentrations(25,50,100 and 200 mg?L~(-1)) on proliferation activity of fibroblast hyperplasia at different time were detected by viable count and MTT chromometry.Results Compared with control group,GS-Rg3 inhibited the proliferation of keloid fibroblasts.The inhibition increased with the prolongation of time and the increasing of concentration.And the max inhibitory concentration was 100 mg?L~(-1).Conclusion Gs-Rg3 can inhibit the proliferation of human keloid fibroblasts cultivated in vitro.And the inhibition will increase with the prolongation of time and the increasing of concentration.