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Inhibitory effects of novel heteropoly compounds on influnenza virus (H1N1) in vitro / 吉林大学学报(医学版)
Article em Zh | WPRIM | ID: wpr-586640
Biblioteca responsável: WPRO
ABSTRACT
Objective To investigate the toxicities and inhibitory effects of three kinds of kegin-type novel heteropoly compounds which were synthesised by molecular assembly interactions on influnenza A virus(H1N1) in vitro.Methods The toxicities and anti-influnenza virus activities were tested by methods of CPE-MTT and chick embryos culture.Results TC_(50) in MDCK cells and LD_(50) in chick embryos of three kinds of kegin-type novel heteropoly compounds were higher than those of amantadine.TI in MDCK cells and chick embryos were both higher than that of amantadine. Conclusion The three kinds of kegin-type novel heteropoly compounds have lower toxicities and higher anti-virus effects on influnenza A virus(H1N1) than amantadine.Through chemic modifications,the toxicity of amantadine can be decreased and the activity of amantadine can be increased.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Journal of Jilin University(Medicine Edition) Ano de publicação: 2006 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Journal of Jilin University(Medicine Edition) Ano de publicação: 2006 Tipo de documento: Article