Drug Resistance and Clinical Distribution of Common Nonfermenters in Nosocomial Infection / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the clinical distribution and drug resistance of the nonfermenters between 2000 and 2004 in our hospital. METHODS The bacteria were identified by ATB,drug resistance test was then performed by K-B method. RESULTS A total of 875 strains of nonfermentative Gram-negative bacteria were isolated from various clinical specimens during Jan 2000-Dec 2004.The dominant strains were Pseudomonas aeruginosa((313 strains)),Acinetobacter baumannii(287 strains) and Stenotrophomonas maltophilia(180 strains).They happened most commonly in the respiratory system.The positive rate from sputum and pharyngeal probe was 73.7% and 6.2%.The resistance rate of P.aeruginosa and A.baumannii to imipenem was the lowest,accounted for 17.6% and 7.7%.These nonfermenters were highly resistant to cefalotin,ceftriaxone and sulfamethoxazole/trimethoprim.The resistance rate of S.maltophilia to sulfamethoxazole/trimethoprim was lower than the others,the rate being 7.8%. CONCLUSIONS The drug resistance of nonfermenters to frequently-used antibacterials is higher.Due to the high resistant rates,the drugs should be chosen according to the result of the drug susceptibility test.