Induction of apoptin on apoptosis of C6 glioma cells / 吉林大学学报(医学版)

ABSTRACT

Objective To explore the induction of apoptin on apoptosis in C6 glioma cells.Methods After having successfully cultivated C6 glioma cells and had an inoculation in Wistar rats,the animal models of Wistar rats bearing C6 glioma were set up.The rats were randomly divided into three groups:tumor control,chemotherapy and pvVP3 groups.Different treatment methods were performed in different groups.The ultrastructural changes and the apoptotic rates were detected with TUNEL.Results Typical changes of apoptosis in pvVP3 group were found through ultrastructural observation,while they could not be found in tumor control group.The apoptotic rate in pvVP3 group(51.11%) was higher than that in control group(28.96%)(P