Correlation of PARP expression with P-selectin and ICAM-1 expression in colorectal carcinoma / 基础医学与临床

ABSTRACT

Objective To investigate the correlation of PARP with the metastasis of colorectal carcinoma.Methods Poly(ADP-ribose) polymerase activity was tested by detecting poly-ADP ribose.Immunohistochemical SP was used to detect the expression of PAR,P-selectin and ICAM-1 in colorectal carcinoma and control colorectal mucosa.The co-expression of PAR with P-selectin and ICAM-1 was investigated by immunofluorescence staining in colorectal carcinoma and control colorectal mucosa.Results The expression of PAR,P-selectin and ICAM-1 was significantly higher in colorectal carcinoma than that in the control colorectal mucosa((P