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Association between mannose-binding lectin gene polymorphism and frequent relapses in childhood nephrotic syndrome / 医学研究生学报
Journal of Medical Postgraduates ; (12)2003.
Artigo em Chinês | WPRIM | ID: wpr-587412
ABSTRACT

Objective:

To determine whether mannose-binding lectin(MBL) variant alleles were associated with frequent relapses in childhood nephrotic syndrome(NS).

Methods:

MBL alleles of codon 54 and promoter region at positions-550 and-221 were genotyped by means of Polymerase Chain Reaction-Restricted Fragment Length Polymorphism(PCR-RFLP)and PCR-Sequence-Specific Primers(PCR-SSP)assay in 32 China Han Nationality children with frequently relapsing NS(FRNS) and 31 with non-frequently relapsing NS(NFRNS),as well as in 32 healthy control subjects.

Results:

In patients with upper respiratory infections before relapses,the mutant genotype(GGC/GAC and GAC/GAC) frequency of MBL codon 54 was higher in children with FRNS(76.0%) than in children with NFRNS(42.9%).The B allele mutation frequency of MBL codon 54 was higher in children with FRNS than in healthy control subjects(34.4% vs 12.5%,P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Medical Postgraduates Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Medical Postgraduates Ano de publicação: 2003 Tipo de documento: Artigo