Sortase:New Target Enzyme in Gram-positive Pathogens / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
;
(12)2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-587465
ABSTRACT
Many surface proteins of Gram-positive bacteria are anchored to the cell wall by the action of sortase enzymes, a recently discovered family of cysteine transpeptidases. As the surface proteins of pathogens are frequently required for virulence, the sortase might be a suitable target for the development of anti-Gram-positive drugs. Recently, the mechanism and active sites of sortase was elucidated by the research of sortaseA(SrtA) in Staphylococcus aureus and a series of SrtA inhibitors have been identified for providing the basis for further development of potent inhibitors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Progress in Biochemistry and Biophysics
Ano de publicação:
2006
Tipo de documento:
Artigo
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