Insulin resistance and function of islet ? cell of the first-degree relatives of T2DM with normal glucose tolerance / 中国糖尿病杂志

ABSTRACT

To investigate the insulin resistance and insulin secretion of the first degree relatives of T2DM with normal glucose tolerance(NGT). The levels of FIns and HOMA-IR in the groups of the parental (n=35) and the maternal (n=58) were higher than that in the group of the paternal (n=42), bwt the IAI and △I_ 30 /△G_ 30 were lower than that in the group of paternal. This suggests the first-degree relatives of type 2 diabetes have insulin resistance and impaired first phase insulin secretion in NGT.