Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
The Korean Journal of Parasitology
;
: 661-665, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-58758
ABSTRACT
We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin (9d-12d) showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parasitos
/
Artemisininas
/
Reação de Cicloadição
Idioma:
Inglês
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS