Effect of amylin on biomechanical properties of the femur in glucocorticoid-induced osteoporosis rats / 医学研究生学报

ABSTRACT

Objective:To investigate the effect of amylin on biomechanical property of the femur in glucocorticoid-induced osteoporosis rats. Methods:Four groups of female Wistar rats(3 months old) were treated for 12 weeks as follows: ⅠNormal Control;ⅡDXM;Ⅲ DXM+AMY;Ⅳ DXM+Vitamin D_3.By intramuscular injection of dexamethasone(DXM)1mg/kg twice a week during the first 8 weeks,the animal model of Glucocorticoid induced osteoporosis was established.After 12 weeks,biomechanical properties of the femur were measured. Results:After the treatment with AMY,Bone structural mechanical(diameter) and geometrical parameters(displacement,peak load) of the femur were significantly increased(vs.DXM group,P