Antigout effect of renierol extracted from the marine sponge in the South China Sea / 中国海洋药物

ABSTRACT

Objective To investigate the inhibitive effect of renierol extracted from the marine sponge in the South China Sea on xanthine oxidase and the effect on mice hyperuricemia as well as its possible mechanisms.Methods Renierol was extracted from sponge and its antigoat effect was tested.The activity of xanthine oxidase was measured by using the generation of uric acid method and the NBT reduction induced by superoxide anions,then its possible mechanism was estimated.Results The two methods showed renierol could obviously inhibit the effect of xanthine oxidase with IC_(50)of 1.85 and 1.36?g?mL~(-1),respectively.Conclusion Renierol extracted from the marine sponge can effectively inhibit the effect of xanthine oxidase.