Expression of TrkA in Wistar rat brain during embryonic phase / 吉林大学学报(医学版)

ABSTRACT

Objective To detect the expression of TrkA in the brain of the Wistar rats during the embryonic phase.Methods Adult Wistar rats were fed in one cage.It was E0 day when sepermia were found in vaginal suppository and vaginal smear.The expressions of TrkA in the brain of Wistar rats during various brain regions were observed by immunohistochemistry on E13,E15,E17,E19 and E21 day. Results On E13 day no obvious expression of TrkA was observed in the embryonic brain.The expression of TrkA had an obviously increasing tendency in the cortex of telencephalon from E15 day to E17 day.And on E17 day,the positive rate of the expression of TrkA reached the second peak.While on E19 day,the expression of TrkA had a temporary decreasing.Then on E21 day the expression of TrkA reached the highest peak.The striatum and hippocampus developed later than the telencephalon till E17 day,and the expressions of TrkA during these stages were same as the cerebrum.Conclusion From E15 to E17 day,obvious expressions of TrkA are observed in the embryonic telencephalon,and it accords with embryonic induction.