Pathogen and Antibiotic Resistance in Very-low-birth-weight or Preterm Infants Septicemia / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To understand the distribution of pathogen in very-low-birth-weight or preterm infants septicemia in early-onset and late-onset and drug sensitivity.METHODS Bacterial isolates from inpatients of very-low-birth-weight or preterm infants septicemia over a period of 3 years were retrospectively analyzed,and classified as when septicemia was happened.RESULTS The positive rate of isolates was 43.2% in 970 samples of very-low-birth-weight or preterm infants septicemia.Most of the sepsis detected by blood culture was late-onset neonatal sepsis(58.6%).Pathogen of late-onset neonatal sepsis mostly was Gram-positive cocci,Staphylococcus were found to be the most common isolates(80.5%).In early-onset sepsis group,the isolates rates of Gram-negative and Gram-positive bacteria were mostly in proportion,there were 52.4% and 47.6%,respeitively.The resistance rate of late-onset sepsis group was higher than that of early-onset one.CONCLUSIONS The key of curing infants septicemia is that we should master the distribution of pathogen of very-low-birth-weight or preterm infants septicemia in early-onset and late-onset and drug sensitivity.Antimicrobial therapy should be initiated under the guidance of anti-microbial sensitivity test,in order to avoid abuse of antimicrobial.