Effects of anti-tumor and immune regulation of several human lactobacillus in mouse / 基础医学与临床

ABSTRACT

Objective To investigate three strains of vaginal Lactobacillus for their regulative effects on macrophage and murine uterocervical carcinoma number 14(U14).Methods Mice were transplanted with U14,then ramdomly divided them into 5 groups.Model group and DDP group respectively were regarded as nagative and positive comparison;Lactobacillus groups were injected with 1010 each with Lactobacillus into peritoneum for 10 days successively.The TNF-? and NO content secreted by KM mice and the inhibitory rate of U14 cells were detected.Results The production of TNF-? and NO secreted by the peritoneal macrophages activated by Lactobacillus was greatly increased.The three strains of Lactobacillus all had significantly antitumor effects on KM mice bearing U14.Conclusion Lactobacillus showed a marked inhibition effects on the U14 cells and can activate macrophages to produce TNF-?and NO which may be involved in the antitumor mechanism.