Expressions of IGF-Ⅰand TGF-?_1 in rats with pulmonary fibrosis / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition)
;
(6)2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-588715
ABSTRACT
Objective To study the expressions of IGF-Ⅰ and TGF-?1 in lung tissue of rats with pulmonary fibrosis.Methods Sixty male Wistar rats were randomly divided into two groups control group(n=20) and experimental group(n=40),and poured respectively by saline and bleomycin solutions,and killed on the 7th,14th,21th,28th day.Immunohistochemistry method was used to analyze the expressions of IGF-Ⅰ and TGF-?1 in lung tissue.Results After 4 weeks induction by bleomycin solutions,the lung tissue was obtained and stained by HE,the pathological changes were in accordance with pulmonary fibrosis.Pulmonary interstitial fibers were found by VG staining.So lung fibrosis models induced by bleomycin were set up successfully.The expressions of IGF-Ⅰ and TGF-?1 were increased during the progression of pulmonary fibrosis.Excellent differences of percentage of positive cells and expression level of IGF-Ⅰ and TGF-?1 were found between control group and experimental group(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Jilin University(Medicine Edition)
Ano de publicação:
2006
Tipo de documento:
Artigo
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