Transsphenoidal approach operation for pituitary adenoma:Report of 48 cases / 中国微创外科杂志

ABSTRACT

Objective To study the effect of transsphenoidal approach operation for pituitary adenoma.Methods Transoral and transsphenoidal approach operations were performed in 17 patients with pituitary adenoma,and transnosal and transsphenoidal approach operations were performed in 31 patients with pituitary adenoma,from January 2000 to December 2005.For transoral and transsphenoidal approach operations,the upper lip mucous membrane was opened to introduce into the nasal cavity.For transnosal and transsphenoidal approach operations,the instruments were inserted by way of the right nostril,and the nasal septum was opened.During both of the approaches,a tunnel was established between both sides of the nasal septum,through which the sphenoidal sinus was opened,for entering the sella through the bottom.Results Total resection was completed in 37 patients,subtotal resection was completed in 6,and partial resection,in 5.No surgical-related death occurred.Postoperatively,transient hyperuresis was found in 15 patients,and cerebrospinal fluid rhinorrhea was seen in 7 patients.Seventeen patients were followed for 3～24 months(mean,12 months).Recurrence was encountered in 4 patients at 6 months after operation.Four patients were pregnant and delivered of a child.Conclusions For pituitay adenoma not obviously extending to the parasellar,transsphenoidal approach is a safe and effective option.