Detection of HLA-G and establishment of prognostic indicator for preeclampsia / 临床检验杂志

ABSTRACT

Objective To pre-diagnose and pre-group preeclamsia by detecting soluble HLA-G(sHLA-G) in serum of pregnant women.Methods Serum sHLA-G was detected with enzyme-linked immunosorbent assay(ELISA) and placental HLA-G was detected for retrospective research by RT-PCR.Results Serum and placental HLA-G decreased significantly in the preeclampsia group compared with normal pregnant females.The levels of sHLA-G in serum were significantly different between the two groups.Conclusion Serum sHLA-G can be measured as a prognostic indictor for the pregnant females who may be potential preeclampsia patients of special types.