Combined Irbesartan and Amiodarone in Maintaining Sinus Rhythm in Patients with Rheumatic Heart Disease after Mitral Valve Replacement / 中华高血压杂志

ABSTRACT

Objective The purpose of the present study was to evaluate the effect of combined irbesartan and amiodarone to maintain sinus rhythm in patients with rheumatic heart disease after valve replacement. Methods One hundred and sixteen patients of rheumatic heart disease after valve replacement operation complicated with persistent atrial fibrillation were randomized to amiodarone monotherapy (n=55) or irbesartan plus amiodarone group(n=61). Electrical cardioversion was administered 2 weeks after of pharmaceutical treatment. Patients were followed up for 18 months. Left atrial diameter was measured at before and 6, 12, 18 months after treatment. Results After 12 months, the left atrial diameter in amiodarone monotherapy group was significantly greater than irbesartan plus amiodarone combined group (P