Mechanism of Protective Immunity Induced by Irradiation-Attenuated Sporozoites and its Implication for Pre-Erythrocytic Malaria Vaccine Research / 中国寄生虫学与寄生虫病杂志

ABSTRACT

Irradiation-attenuated sporozoites are still the most effective pre-erythrocytic malaria vaccine.However,limitation of purified sporozoites and difficulty in attenuation controlling of sporozoites hamper its use in practice.Understanding the mechanism of protective immunity induced by irradiation-attenuated sporozoites will be helpful for the design of the efficient pre-erythrocytic malaria vaccine.This is a review on research progress in the mechanism of protective immunity induced by irradiation-attenuated sporozoites and current status of pre-erythrocytic malaria vaccine development.