Effects of tea polyphenol on oligodendrocyte in cerebral ischemic rats / 临床神经病学杂志

ABSTRACT

Objective To investigate the effects of tea polyphenol on oligodendrocyte(OLG) in the cerebral ischemic rats. Methods Male Sprague Dawley rats were randomly divided into sham-operated group, control group and tea polyphenol group. The models of whole-brain ischemia were established . Then the rats of tea polyphenol group were divided another 3 groups and injected intraperitoneally with tea polyphenol at diffenrent dose (25 mg/kg, 50 mg/kg, 100 mg/kg, respectively) once a day for seven days . The expressions of precursor OLG cells, pedo-OLG cells and mature OLG cells in the cortex were examined by immunohistochemistry and the positive cells were counted.Results Compared with sham-operated group, the number of precursor OLG cells increased and the number of pedo-OLG cells and mature OLG cells decreased significantly in the control group (all P