Neurodevelopmental Changes in Social Reinforcement Processing: A Functional Magnetic Resonance Imaging Study
Clinical Psychopharmacology and Neuroscience
;
: 369-381, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-58957
ABSTRACT
OBJECTIVE:
In the current study we investigated neurodevelopmental changes in response to social and non-social reinforcement.METHODS:
Fifty-three healthy participants including 16 early adolescents (age, 10–15 years), 16 late adolescents (age, 15–18 years), and 21 young adults (age, 21–25 years) completed a social/non-social reward learning task while undergoing functional magnetic resonance imaging. Participants responded to fractal image stimuli and received social or non-social reward/non-rewards according to their accuracy. ANOVAs were conducted on both the blood oxygen level dependent response data and the product of a context-dependent psychophysiological interaction (gPPI) analysis involving ventromedial prefrontal cortex (vmPFC) and bilateral insula cortices as seed regions.RESULTS:
Early adolescents showed significantly increased activation in the amygdala and anterior insula cortex in response to non-social monetary rewards relative to both social reward/non-reward and monetary non-rewards compared to late adolescents and young adults. In addition, early adolescents showed significantly more positive connectivity between the vmPFC/bilateral insula cortices seeds and other regions implicated in reinforcement processing (the amygdala, posterior cingulate cortex, insula cortex, and lentiform nucleus) in response to non-reward and especially social non-reward, compared to late adolescents and young adults.CONCLUSION:
It appears that early adolescence may be marked by (i) a selective increase in responsiveness to non-social, relative to social, rewards; and (ii) enhanced, integrated functioning of reinforcement circuitry for non-reward, and in particular, with respect to posterior cingulate and insula cortices, for social non-reward.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Reforço Social
/
Recompensa
/
Imageamento por Ressonância Magnética
/
Córtex Pré-Frontal
/
Fractais
/
Voluntários Saudáveis
/
Giro do Cíngulo
/
Tonsila do Cerebelo
/
Aprendizagem
Limite:
Adolescente
/
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2017
Tipo de documento:
Artigo
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