Polymorphism of human platelet antigens 1 to 16 in Zhejiang Han population / 中国输血杂志

ABSTRACT

Objective To investigate the genetic polymorphism of HPA-1 to-16 antigens in Zhejiang Han population.Methods A total of 120 samples from unrelated donors of Zhejiang were genotyped by Polymerase Chain Reaction with Sequence-Specific Primers(PCR-SSP).Results The allele frequencies of HPA-1b,-2b,-3b,-6bw,-15b were 0.0125,0.0542,0.3833,0.0125 and 0.4833,respectively.HPA-4b,-5b,-7bw,-8bw,-9bw,-10bw,-11bw,-12bw,-13bw,-14bw and-16bw alleles were not detected.The mismatch probability(MP) of HPA-3 and 15 were 0.36 and 0.37,respectively,in raneom platelet transfusion.Conclusion There is no difference of HPA polymorphism distribution between Han population in Zhejiang and those in other areas of China.The polymorphism of HPA-3 and-15 are more abundant than other HPA antigens,so they may cause alloimmunity in random platelet transfusion recipients and between mothers and fetuses.