Technetium-99 conjugated with methylene diphosphonate:An effective agent for adjuvant arthritis in rats / 医学研究生学报
Journal of Medical Postgraduates
; (12)2004.
Article
em Zh
| WPRIM
| ID: wpr-590954
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To analyze the effects of technetium99 conjugated with methylene diphosphonate(99Tc-MDP) on adjuvant arthritis in rats.Methods: Thirty SD rats were randomly and equally divided into a normal control group an adjuvant arthritis control group and a 99Tc-MDP treatment group.Intraperitoneal injection of 99Tc-MDP(2.5?10-3?g/kg) was given to the rats in the treatment group on the tenth day and repeated every other day after arthritis induction.The left-right diameter of the left hind ankle,arthritic index,serum TNF and IL-1? levels,articular radionuclide imaging and histopathological changes were observed.Results: Compared with the adjuvant arthritis group,the diameter of the left hind ankle,arthritic index,the serum TNF and IL-1? levels and the T/NT value were decreased in the treatment group,and histopathology showed less synovium hyperplasia and fewer infiltration of inflammatory cells in the group treated with 99Tc-MDP intraperitoneal injection than in the adjuvant arthritis control group.Conclusion: 99Tc-MDP intraperitoneal injection is effective for adjuvant arthritis in rats.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2004
Tipo de documento:
Article