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Cloning and Identification of Promoter of Human LCRG1 Gene / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics ; (12)2006.
Artigo em Chinês | WPRIM | ID: wpr-591926
ABSTRACT
Laryngeal carcinoma related gene 1(LCRG1) is a candidate tumor suppressor gene of Laryngeal carcinoma. To further investigate its transcriptional regulation, the transcriptional start sites for LCRG1 gene have been identified by 5′ RACE (rapid amplification of cDNA ends) based on the bioinformation analysis of LCRG1. Then eleven luciferase expression vectors which contained potential human LCRG1 gene promoter were constructed. Luciferase reporter assay indicated that LCRG1 promoter region was mainly located in -169~+127 region nearby the major transcriptional start site. These results suggested that the region (-169~+127) includes an essential promoter for human LCRG1 gene transcription.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico Idioma: Chinês Revista: Progress in Biochemistry and Biophysics Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico Idioma: Chinês Revista: Progress in Biochemistry and Biophysics Ano de publicação: 2006 Tipo de documento: Artigo