Progress in gene therapy for intervertebral disc degeneration / 中国组织工程研究

ABSTRACT

With deeper understanding for intervertebral disc degeneration,the development and clinical application of protocols in molecular biology,biological intervention in initial stage of intervertebral disc degeneration can retard even reverse the degeneration process. Gene therapy of intervertebral disc degeneration refers to the selection of animal models and gene carriers,application of target genes,etc. It is the key for gene therapy to build human-like animal model,select proper gene carrier and apply ideal target genes. Prior to clinical application,the safety and efficacy of gene therapy should be proved,thus many problems deserve further study.