Antibiotic Resistance of Streptococcus pneumoniae Isolates from Children′s Sputum / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To study the patterns of the resistance to erythromycin mediated by ermB and mefE in Streptococcus pneumoniae isolates in children.METHODS Totally 1012 sputums obtained from upper and lower respiratory tract of children were collected.Clindamycin disks were used to detect macrolide resistance mediated by ermB and mefE in S.pneumoniae isolates from children.RESULTS 252 nonduplicate clinical isolates of S.pneumoniae obtained.the ermB gene(63.6%) was predominant among isolates from children,while mefE was 36.4%.CONCLUSIONS Isolates containing ermB gene are highly resistant to clindamycin.The resistance mediated by ermB is higher than that by mefE.