Antibiotic-resistant Genetical Marks of Integron and Transposon in Pseudomonas aeruginosa Strains Isolated in Two Hospitals / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the antibiotic resistance and the genetical marks in Pseudomonas aeruginosa(PAE) strains in two hospitals of Jiangsu and Zhejiang.METHODS The drug-resistance in PAE strains was detected with K-B test,four kinds of genetical marks of integron and transposon(qacE△1-sul1,mer,tnpA and tnpU) were detected by PCR.RESULTS The strains were only sensitive to cefoperazone/sulbactam,imipenem,meropenem and amikacin.There was a high resistance rate to ?-lactamases,ciprofloxacin,and sulfamethoxazole.Genes of qacE△1-sul1(48.6%,45.0%) and merA(11.4%,5.0%) were detected from PAE strains in the two hospitals.There were no tnpA and tnpU too.CONCLUSIONS Multiple-drug-resistance in Pseudomonas aeruginosa(PAE) strains is caused mainly by qacE△1-sul1 and merA.