Genes of SMZco Resistance in Drug-resistant Shigella Strains / 中华医院感染学杂志
Chinese Journal of Nosocomiology
; (24)2006.
Article
em Zh
| WPRIM
| ID: wpr-593707
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE To investigate mechanisms of sulfamethoxazolel trimethoprim(SMZco) resistance in multi-drug-resistant strains of Shigella.METHODS The strains of multi-resistant Shigella were selected with K-B susceptibility method.The genes(sul1,dfrA1,dfrA5,dfrA12 and dfrA17) of SMZco resistance were detected by polymerase chain reaction(PCR).And using the DNA sequencing determined that bears the genotype.RESULTS In 20 Shigella strains the drug-resistance rate of Shigella to SMZco was 95.0%.Sul1,dfrA1,dfrA12 and dfrA17-positive rate was 15.0%,100.0%,5.0% and 0,DfrA1 positive gene sequencing showed highly homology with the sequence of GenBank.CONCLUSIONS There is a close relation of the SMZco resistance in Shigella to sul1 and dfrA1 existing.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Nosocomiology
Ano de publicação:
2006
Tipo de documento:
Article