Investigate on the polymorphism of brain-derived neurotrophic factor gene C270T in patients with sporadic Alzheimer's disease / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)1988.
Artigo
em Chinês
| WPRIM
| ID: wpr-594559
ABSTRACT
Objective To investigate the association between the polymorphisms of brain-derived neurotrophic factor(BDNF) gene C270T and sporadic Alzheimer's disease(SAD) in Han Chinese.Methods The polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP) was used to detect BDNF gene C270T genotype and allele frequencies in 55 SAD patients and 80 age-and sex-matched healthy people(as normal control group).Results The frequencies distribution of BDNF gene C270T genotype and allele in the normal control group were suit to Hardy-Weinberg equilibrium(?2=0.167,P=0.682).The frequencies distribution of genotype and allele in the SAD group[C/C52(94.5%),C/T3(5.5%) and C97.27%,T2.73%]and normal control group[C/C74(92.5%),C/T6(7.5%) and C96.25%,T3.75%] were no statistical differences.Conclusion There is no association between the polymorphisms of BDNF gene C270T and SAD in Han Chinese.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Clinical Neurology
Ano de publicação:
1988
Tipo de documento:
Artigo
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