Diagnostic value of clusterin for follicular dendritic cell sarcoma/tumor and anaplastic large cell lymphoma / 医学研究生学报

ABSTRACT

Objective:Clusterin is highly expressed in lymphoid and hematopoietoid tissue tumors in literature.This study is to investigate the significance of clusterin in the diagnosis of tumors by detecting its expression in follicular dendritic cell sarcoma/tumor(FDCS/T) and anaplastic large cell lymphoma(ALCL).Methods: The expression of clusterin was detected by immunohistochemical method in ALCL,diffuse large B-cell lymphoma(DLBCL),follicular lymphoma(FL),mantle cell lymphoma(MCL),NK/T-cell lymphoma(NK/T),peripheral T-cell lymphoma(PTL),plasma cell lymphoma(PCL),classical Hodgkin lymphoma(CHL) and FDCS/T.The expressions of CD30 and ALK in ALCL,and of CD21+CD35 in FDCS/T were also detected,and so were those of clusterin and CD21+CD35 in 10 cases of reactive hyperplasia of the lymph node were detected.Results: Clusterin and CD21+CD35 were both expressed in 8 cases of FDCS/T.The positive expression rates of clusterin,CD30 and ALK1 in 20 cases of ALCL were 85.00%(17/20),100%(20/20) and 50.00%(10/20),respectively.Clusterin was expressed in 4.70% of the 85 DLBCL cases(4/85),but not in other lymphoma tissues;clusterin and CD21+CD35 were both expressed in 100% of the 2 FDCS/T cases,and they were also expressed in reactive hyperplasia of lymph nodes as well as in follicular dendritic cells,but not in B-and T-cells.Conclusion: Clusterin might be a new marker for follicular dendritic cells,helpful to the diagnosis and differential diagnosis of ALCL.