Relationship of atherosclerosis with rheumatoid arthritis and systemic lupus erythematosus / 医学研究生学报

ABSTRACT

Rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE) are autoimmune disorders.The incidence and morbidity of coronary artery disease are much higher in patients with RA and SLE than in the general population.Traditional cardiovascular risk factors do not fully explain the excessive cardiovascular events.Some new factors,such as high cysteine,insulin resistance,metabolic syndrome and inflammation,may play an important role in the development of atherosclerosis.Inflammatory response,endothelial damage and autoantibodies may be associated with the pathogenic mechanism.This review provides an overview of atherosclerosis in RA and SLE.