Change of plasma endogenous hydrogen sulfide content before and after late open vasculature in patients with myocardial infarction and its significance / 心血管康复医学杂志

ABSTRACT

Objective: To explore change of plasma endogenous hydrogen sulfide content before and after late open vasculature in patients with myocardial infarction and its significance. Methods: A total of 60 patients with primary myocardial infarction, who didn’t receive thrombolytic therapy and lesion locations had been confirmed by coronary angiography, were divided into group of successfully open after occlusion in proximal segment of left anterior descending artery (LAD group, n=20), group of successfully open after occlusion in proximal segment of right coronary artery (RCA group, n=20) and group of successfully open after occlusion in proximal segment of both above arteries (LAD + RCA group, n=20). Spectrophotometry method was used to measure concentration of endogenous H2S before and after open vasculature in all groups. Results: Compared with endogenous H2S level before open vasculature, there were significant increase in endogenous H2S level in LAD group [(24.44+3.27) μmol/L vs. (37.47+2.38) μmol/L], RCA group [(24.48+3.60) μmol/L vs. (37.22+2.56) μmol/L] and LAD + RCA group [(20.41+2.22) μmol/L vs. (30.34+2.37) μmol/L] after open vasculature, P<0.05 all. Conclusion: Concentration of endogenous hydrogen sulfide significantly increases after open vasculature in patients with myocardial infarction; it may be beneficial for prognosis of patients.