Effects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery / 대한마취과학회지
Korean Journal of Anesthesiology
; : 105-111, 2013.
Article
em En
| WPRIM
| ID: wpr-59815
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Both systemic inflammatory reaction and regional myocardial ischemia/reperfusion injury may elicit hypercoagulability after off-pump coronary artery bypass grafting (OPCAB). We investigated the influence of ulinastatin, which suppresses the activity of polymorphonuclear leukocyte elastase and production of pro-inflammatory cytokines, on coagulation in patients with elevated high-sensitivity C-reactive protein (hsCRP) undergoing OPCAB. METHODS: Fifty patients whose preoperative hsCRP > 3.0 mg/L were randomly allocated into the ulinastatin (600,000 U) or control group. Serum concentrations of thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2) were measured preoperatively, immediately after surgery, and at 24 h after surgery, respectively. Secondary endpoints included platelet factor (PF)-4, amount of blood loss, and transfusion requirement. RESULTS: All baseline values of TAT, F1+2, and PF-4 were higher than the normal range in both groups. F1+2 was elevated in both groups at immediate, and at 24 h after surgery as compared to baseline value, without any significant intergroup differences. Remaining coagulation parameters, transfusion requirement and blood loss during operation and postoperative 24 h were not different between the two groups. CONCLUSIONS: Intraoperative administration of ulinastatin did not convey beneficial influence in terms of coagulation and blood loss in high-risk patients with elevated hsCRP undergoing multivessel OPCAB, who already exhibited hypercoagulability before surgery.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Peptídeo Hidrolases
/
Valores de Referência
/
Plaquetas
/
Proteína C-Reativa
/
Protrombina
/
Glicoproteínas
/
Antitrombina III
/
Citocinas
/
Elastase de Leucócito
/
Trombofilia
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2013
Tipo de documento:
Article