Influence of fluvastatin on carotid intima-media thickness and pulse pressure in patients with hypertension / 心血管康复医学杂志

ABSTRACT

Objective: To analyze influence of fluvastatin on carotid intima-media thickness (IMT) and pulse pressure (PP) in patients with essential hypertension (EH). Methods: A total of 62 EH patients were enrolled and randomly divided into fluvastatin group (n=32, received fluvastatin therapy based on routine antihypertensive therapy) and routine treatment group (n=30, received routine antihypertensive therapy). Course of treatment was one year for all patients. Levels of blood lipids, PP and carotid IMT were compared between two groups before, six and 12 months after treatment. Results: Compared with before treatment, there were significant decrease in levels of all blood lipids, PP [(66.9±7.3) mmHg vs. (53.1±6.2) mmHg] and IMT [(0.97±0.42) mm vs. (0.76±0.29) mm] in fluvastatin group after treatment six and 12 months, and significantly improved more than those of routine treatment group, P0.05）. Conclusion: Fluvastatin can improve carotid intima-media thickness and pulse pressure in patients with hypertension and is worth extending in clinic.