Relation between hepatic lipase promoter-514C/T polymorphism and coronary heart disease / 心血管康复医学杂志

ABSTRACT

Objective: To explore the relation between hepatic lipase (HL) promoter-514C/T polymorphism and coronary heart disease (CHD) in population of this district. Methods: Polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) was used to measure HL promoter-514C/T genotypes in 199 CHD patients (CHD group) and 146 non-CHD patients (non-CHD group) in order to explore its influence on blood lipids and apolipoprotein. Results: In male group, there was significant difference in distribution of HL promoter-514C/T genotype between CHD group and non-CHD group (χ2=15.851，P=0.015); but there was no significant difference in female group (χ2=0.249，P=0.969); Compared with LIPC-514-C/T CC male inpatients, there was significant increase in level of high density lipoprotein cholesterol [(34.6±8.9)mg/dl vs. (38.9±10.2)mg/dl, P=0.02] in CT/TT male inpatients. Conclusion: Hepatic lipase promoter-514C/T polymorphism has certain influence on levels of blood lipids in patients with coronary heart disease.