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The preparation of inclusion compound of diclofenac sodium-β-cyclodextrin / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 153-1998.
Artigo em Chinês | WPRIM | ID: wpr-598328
ABSTRACT

OBJECTIVE:

To prepare the inclusion compound of diclofenac sodium (DFS)-β-cyclodextrin (β-CD) and investigate its properties.

METHOD:

The inclusion compound of DFS-β-CD was prepared by the co-precipitation method.

RESULTS:

The inclusion compound of DFS-β-CD was confirmed by UV absorption spectrum, IR absorption spectroscopy, differential scanning calorimetry (DSC) and phase solubility diagram. Meanwhile, the content analysis of the inclusion compound showed that the molecular ratio of DFS to β-CD was 1∶1.

CONCLUSION:

The soluability and dissolution rate of DFS were increased and its irritation to stomach was reduced when the drug was included by β-CD.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 1998 Tipo de documento: Artigo