Striatal CREB Phosphorylation Following Cued/Response Learning in the Water Maze Differ in Two Inbred Strains of Mice
Experimental Neurobiology
;
: 41-46, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-59837
ABSTRACT
Much evidence shows that the hippocampus and striatum play roles as important neural substrates for spatial/place and cued/response learning, respectively. This experiment was conducted to investigate the engagement of the striatum in cued/response learning. The engagement of the striatum was assessed after either place or cue training by determining levels of cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB) in these two mouse strains. Results revealed that striatal CREB levels in both strains of mice were not significantly increased after cued/response learning comparing to place training mediated by the hippocampus. However, striatal pCREB of DBA/2 mice was significantly higher after cued/response training in comparison to place learning, while striatal pCREB levels on C57BL/6 mice did not differ in cued learning versus place learning. These findings indicate that striatal pCREB, specifically associated with cued/response learning, is closely tied to differences in cued/responses strategy preference between C57BL/6 and DBA/2 mice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Oftalmoplegia
/
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
/
Aprendizagem em Labirinto
/
Sinais (Psicologia)
/
Doenças Mitocondriais
/
Hipocampo
/
Hipogonadismo
/
Aprendizagem
/
Camundongos Endogâmicos
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental Neurobiology
Ano de publicação:
2008
Tipo de documento:
Artigo
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