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Computational Approach for Biosynthetic Engineering of Post-PKS Tailoring Enzymes
Genomics & Informatics ; : 227-230, 2008.
Artigo em Inglês | WPRIM | ID: wpr-59840
ABSTRACT
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive activities. Many of these compounds and their semisynthetic derivatives are used today in the clinic. Most of the gene clusters encoding commercially important drugs have also been cloned and sequenced and their biosynthetic mechanisms studied in great detail. The area of biosynthetic engineering of the enzymes involved in polyketide biosynthesis has recently advanced and been transferred into the industrial arena. In this work, we introduce a computational system to provide the user with a wealth of information that can be utilized for biosynthetic engineering of enzymes involved in post-PKS tailoring steps. Post-PKS tailoring steps are necessary to add functional groups essential for the biological activity and are therefore important in polyketide biosynthesis.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Família Multigênica / Células Clonais Idioma: Inglês Revista: Genomics & Informatics Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Família Multigênica / Células Clonais Idioma: Inglês Revista: Genomics & Informatics Ano de publicação: 2008 Tipo de documento: Artigo