Computational Approach for the Analysis of Post-PKS Glycosylation Step
Genomics & Informatics
;
: 223-226, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-59841
ABSTRACT
We introduce a computational approach for analysis of glycosylation in Post-PKS tailoring steps. It is a computational method to predict the deoxysugar biosynthesis unit pathway and the substrate specificity of glycosyltransferases involved in the glycosylation of polyketides. In this work, a directed and weighted graph is introduced to represent and predict the deoxysugar biosynthesis unit pathway. In addition, a homology based gene clustering method is used to predict the substrate specificity of glycosyltransferases. It is useful for the rational design of polyketide natural products, which leads to in silico drug discovery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Especificidade por Substrato
/
Simulação por Computador
/
Glicosilação
/
Glicosiltransferases
/
Policetídeos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2008
Tipo de documento:
Artigo
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